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← CockpitCompetitor Analysis › PSNL Personalis, Inc.Open in the cockpit ↗

Personalis, Inc.PSNLCompetitor analysis, valuation and peers

United States · USD·Health Care›Medical/Nursing Services

Genomics company providing advanced tumor and immune profiling tests to guide cancer treatment and monitor recurrence.

Momentum leader 98
Mkt cap
$1.71B
US dollars, full cap
Free float
67%
of shares outstanding
$/day
$38.3M
20-day average traded
Fwd P/E
n/m
no positive forecast
ROIC−WACC
-165.9 pp
WACC 16.6%
Hurdle
n/a
no reverse DCF
Next earnings
111 days
25 Feb 2027
Close · USD$15.79
1D+1.5%
1W-0.2%
1M-1.7%
3M+8.9%
6M+164.1%
YTD+98.4%
1Y+106.1%
ATR %2.0%
Beta2.46
52w lowhigh16.4% off high

What Personalis does

Genomics company providing advanced tumor and immune profiling tests to guide cancer treatment and monitor recurrence.

Has long been paid mainly by drug developers for sequencing and tumour analysis in their trials, with a large share from one customer, Moderna. The NeXT Personal blood test, which looks for traces of cancer left after treatment, is the growth bet; its sales to clinicians depend on payers agreeing to cover it.

Products and services

  • NeXT Personal (minimal residual disease test)
  • Tumor profiling/immune-oncology testing
  • Pharma biomarker research services

Customers

  • Oncologists
  • Pharmaceutical/biotech companies (biomarker resear

Where it sits in the supply chain

  • Diagnostics
  • Cancer genomics
  • Comprehensive tumor/immune profiling…

What could go right

  • Minimal residual disease testing adoption growth
  • Pharma biomarker/companion diagnostic demand

What could go wrong

  • Reimbursement/payer coverage uncertainty
  • Cash burn/path-to-profitability risk

Moat: narrow (IP / patents, data). Proprietary highly-sensitive minimal-residual-disease test differentiates from broader liquid-biopsy competitors.

Headquarters: Fremont, California · Founded: 2011 · Employees: 260

Named competitors

Personalis at a glance

Size Personalis (PSNL) is a United States Health Care company (Medical/Nursing Services) with a market value of $1.71B, the 1895th largest of 3,117 United States companies the cockpit tracks. Shares closed at $15.79 on 6 Nov 2026.

Performance Over six months the shares gained 164.1%, against +22.8% for the median peer and -1.1% for the United States market (cap-weighted) — highest of 21 in its peer set.

Growth Revenue fell 13.3% over the last twelve months (peer median +5.9%); the operating margin is -164.1% (peer median 3.2%).

Valuation It trades at 22.1× enterprise value to sales against a peer median of 2.2× (most expensive of 21).

Capital Return on invested capital runs 165.9 points below its cost of capital (16.6% WACC).

Short interest Short interest is 6.3% of the free float (15 Oct 2026).

Next results Next results expected around 25 Feb 2027 (exchange calendar; dates can move).

Relative performance

10020030011 May 202611 Aug 20266 Nov 2026PSNL 273Peer median 125
Six months, rebased to 100: Personalis against the median of its 20 peers (local-currency closes).

Personalis financials

Reported figures in USD; fiscal year ends 2025-12-31. TTM = trailing twelve months.
TTMFY2025FY2024FY2023FY2022
Revenue$69.7M$69.6M$84.6M$73.5M$65.0M
Revenue growth—-18%+15%+13%—
Gross profit$8.84M$15.8M$26.8M$18.2M$13.3M
EBITDA-$105M-$78.0M-$57.3M-$85.0M-$103M
Net income-$107M-$81.3M-$81.3M-$108M-$113M
Free cash flow-$101M-$79.5M-$46.8M-$67.2M-$120M
Capital expenditure$8.68M$4.50M$1.60M$10.9M$49.9M
Total debt$38.0M$40.8M$44.4M$49.0M$49.0M

Quarterly statements and history in the cockpit →

Personalis competitor charts

The default views of Competitor Analysis ▸ Charts, drawn from the same data. Open them in the cockpit to change the axes, pin companies and read every value.

Performance: 6-month against 1-month return

0%+50%+100%+150%0%+20%AZTAAGARWALEYE1833AMBEAVIJAYATDOCSNDAWGSAGLEMEIS300244USPH603882CLARINEODIAOPKLMRIPSNL6-month return →1-month return →
Up and to the right = strong over both horizons. Personalis is the large dot.

Fundamentals: revenue growth against valuation

-10%0%+10%+20%0×10×20×AZTAAGARWALEYE1833AMBEAVIJAYATDOCSNDAWGSAGLEMEIS300244USPH4544DIAOPKPSNLRevenue growth (TTM) →EV / Sales →
Further right = faster growth; higher = more expensive. The dashed lines are the peer medians. Personalis is the large dot.

Personalis competitors and peer comparison

Head to head with its named competitors (PSNL vs GH vs NTRA)
CompanyMarket cap6M returnRevenue growthOp. marginEV / SalesReq g
Personalis PSNL$1.71B+164%-13%-164%22.1×n/a
Guardant Health GH$20.2B+58%+43%-40%17.7×n/a
Natera NTRA$44.8B+60%+38%-11%16.2×n/a

How Personalis compares with its peers

Peer set: Industry: the same industry and sector in any market, nearest in size. This is the same default set the interactive Competitor Analysis opens with.

Personalis against its 20 peers (data as of 6 Nov 2026)
MeasurePSNLPeer medianRank in peer set
1-month return-1.7%+8.0%4th lowest of 21
6-month return+164.1%+22.8%highest of 21
Distance from 52-week high-16.4%-16.0%11th highest of 21
Revenue growth (TTM)-13.3%+5.9%lowest of 21
Operating margin-164.1%3.2%lowest of 21
EV / Sales22.1×2.2×most expensive of 21
ROIC minus cost of capital-165.9 pp-4.1 pplowest of 20

Peer table

Peer set: Industry: the same industry and sector in any market, nearest in size
CompanyMarketMarket cap6M returnRevenue growthOp. marginEV / SalesReq gDelivered g
Personalis PSNLUnited States$1.71B+164%-13%-164%22.1×n/an/a
Azenta AZTAUnited States$1.72B+104%+1%-3%2.4×56.0%+8.9%
Dr. Agarwal's Health Care AGARWALEYE.NSIndia$1.74B+15%+22%15%7.4×41.9%+26.9%
Ping An Healthcare and Technology 1833.HKHong Kong$1.63B-47%+8%3%0.7×15.0%-5.1%
Ambea AMBEA.STSweden$1.63B+30%+13%8%1.7×1.7%+7.7%
Vijaya Diagnostic Centre VIJAYA.NSIndia$1.60B+22%+24%32%16.8×39.3%+16.7%
Teladoc Health TDOCUnited States$1.60B+21%-2%-5%0.7×-5.2%+18.3%
Sonida Senior Living SNDAUnited States$1.58B-14%+49%-11%5.9×n/an/a
GeneDx WGSUnited States$1.86B+53%+25%-12%4.2×n/an/a
agilon health AGLUnited States$1.90B+109%0%-4%0.3×n/an/a
Emeis EMEIS.PAFrance$1.94B-30%+4%3%1.6×21.3%+8.5%
Dian Diagnostics 300244.SZChina$1.97B+11%-5%9%1.5×2.4%-1.1%
U.S. Physical Therapy USPHUnited States$1.48B+68%+11%10%2.7×19.9%+13.0%
Guangzhou Kingmed Diagnostics 603882.SSChina$1.99B+5%-3%7%2.0×6.7%-6.1%
Clariane CLARI.PAFrance$1.40B-20%+1%6%1.6×6.7%+6.5%
H.U.Group 4544.TJapan$1.35B+24%+1%2%0.9×10.1%+2.1%
NeoGenomics NEOUnited States$2.18B+88%+11%-6%3.2×n/an/a
Diagnostyka DIA.WAPoland$1.29B-5%+19%15%2.4×6.9%+18.9%
OPKO Health OPKUnited States$1.29B+52%-11%-29%2.4×n/an/a
Lumexa Imaging LMRIUnited States$1.29B+29%+8%3%2.1×n/an/a
AddLife ALIF-B.STSweden$2.29B+25%+2%8%2.5×21.6%+14.6%

Questions

Who are Personalis's main competitors?
Named competitors: Guardant Health (GH), Natera (NTRA), Exact Sciences (private or unlisted). The cockpit's measured peer set (industry) also includes Azenta (AZTA), Dr. Agarwal's Health Care (AGARWALEYE.NS), Ping An Healthcare and Technology (1833.HK), Ambea (AMBEA.ST), Vijaya Diagnostic Centre (VIJAYA.NS), Teladoc Health (TDOC).
Is Personalis expensive compared with its peers?
On ev / sales it trades at 22.1× against a peer median of 2.2×, most expensive of 21 in its peer set.
How has Personalis stock performed?
Over six months to 6 Nov 2026 the shares returned +164.1% against +22.8% for the median peer; over one year +106.1%.

How these numbers are made. Returns are close-to-close in local currency. Revenue growth and margins are trailing twelve months. Req g is the revenue growth that today's enterprise value requires for seven years at the company's own cost of capital; Delivered g is what it actually grew; the gap is the hurdle (honest precision about ±8 points, so read the ranking more than the decimal). No fair values, price targets or analyst ratings are shown, by design. Method and validation.