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← CockpitCompetitor Analysis › MGTX MeiraGTx Holdings PlcOpen in the cockpit ↗

MeiraGTx Holdings PlcMGTXCompetitor analysis, valuation and peers

United States · USD·Health Care›Biotechnology

Develops AAV gene therapies for inherited retinal diseases, neurodegenerative disorders and salivary gland disease.

Momentum weak 21
Mkt cap
$864M
US dollars, full cap
Free float
77%
of shares outstanding
$/day
$6.37M
20-day average traded
Fwd P/E
n/m
no positive forecast
ROIC−WACC
+68.2 pp
WACC 9.8%
Hurdle
-49 pp
Req g minus delivered
Next earnings
12 days
18 Nov 2026
Close · USD$9.00
1D+5.8%
1W-5.2%
1M-14.3%
3M-30.9%
6M-8.3%
YTD+13.2%
1Y+4.9%
ATR %6.0%
Beta1.66
52w lowhigh41.4% off high

What MeiraGTx does

Develops AAV gene therapies for inherited retinal diseases, neurodegenerative disorders and salivary gland disease.

Has no product on sale; income so far has come from partnership payments rather than sales, and trials are funded by those deals and investor money. It makes its own gene-therapy vectors at in-house plants rather than relying on contract manufacturers.

Products and services

  • Botaretigene sparoparvovec (X-linked retinitis pigmentosa)
  • AAV-GAD (Parkinson's disease)
  • Salivary gland gene therapy for radiation-induced xerostomia

Customers

  • Ophthalmologists/neurologists (post-approval)

Where it sits in the supply chain

  • Health Care
  • Biotechnology
  • AAV gene therapy platform

What could go right

  • Pivotal trial data readouts
  • In-house manufacturing scale advantage

What could go wrong

  • Clinical trial failure risk
  • Cash runway and financing needs

Moat: narrow (IP / patents, process know-how). Vertically integrated in-house AAV manufacturing platform across multiple gene therapy indications.

Headquarters: New York City, US · Founded: 2015 · Employees: 403

Named competitors

MeiraGTx at a glance

Size MeiraGTx (MGTX) is a United States Health Care company (Biotechnology) with a market value of $864M, the 2338th largest of 3,117 United States companies the cockpit tracks. Shares closed at $9.00 on 6 Nov 2026.

Performance Over six months the shares fell 8.3%, against -19.9% for the median peer and -1.1% for the United States market (cap-weighted) — 4th highest of 19 in its peer set.

Growth Revenue grew 948.4% over the last twelve months (peer median -1.8%); the operating margin is 45.9% (peer median -25.3%).

Valuation It trades at 2.1× enterprise value to sales against a peer median of 7.6× (2nd cheapest of 18).

Price implies For today's price to make sense, revenue must grow about -10% a year for seven years (Req g). Recent delivered growth is +39%, so the hurdle is -49 pp: the price already allows for a slowdown.

Capital Return on invested capital runs 68.2 points above its cost of capital (9.8% WACC).

Short interest Short interest is 6.7% of the free float (15 Oct 2026).

Next results Next results expected around 18 Nov 2026 (exchange calendar; dates can move).

Relative performance

7510012515011 May 202611 Aug 20266 Nov 2026MGTX 91Peer median 80
Six months, rebased to 100: MeiraGTx against the median of its 20 peers (local-currency closes).

MeiraGTx financials

Reported figures in USD; fiscal year ends 2025-12-31. TTM = trailing twelve months.
TTMFY2025FY2024FY2023FY2022
Revenue$398M$81.4M$33.3M$14.0M$15.9M
Revenue growth—+145%+137%-12%—
Gross profit$377M$64.0M-$3.34M$287,000$7.20M
EBITDA$195M-$94.8M-$151M-$123M-$108M
Net income$79.0M-$114M-$148M-$84.0M-$130M
Free cash flow$10.5M-$50.2M-$109M-$126M-$118M
Capital expenditure$3.63M$4.24M$4.96M$20.2M$45.0M
Total debt$112M$88.7M$84.8M$89.3M$92.2M

Quarterly statements and history in the cockpit →

MeiraGTx competitor charts

The default views of Competitor Analysis ▸ Charts, drawn from the same data. Open them in the cockpit to change the axes, pin companies and read every value.

Performance: 6-month against 1-month return

-50%0%+50%+100%-25%0%+25%2160SNDX4587PRMEOXBGLUEIVA6885269887301333301520002038JBIO9966ANRO688221MGTX6-month return →1-month return →
Up and to the right = strong over both horizons. MeiraGTx is the large dot.

Fundamentals: revenue growth against valuation

0%+250%+500%+750%+1,000%0×5,000×10,000×15,000×2160SNDX4587IVA688221MGTXRevenue growth (TTM) →EV / Sales →
Further right = faster growth; higher = more expensive. The dashed lines are the peer medians. MeiraGTx is the large dot.

Capital: growth delivered against growth the price implies

0%+20%+40%0%20%40%688526301333301520002038600195300841688221MGTXGrowth delivered (Del g) →Growth the price implies (Req g, 7 yrs) →
Above the diagonal = the price needs more growth than the company has been delivering; below = the price already allows for a slowdown. MeiraGTx is the large dot.

MeiraGTx competitors and peer comparison

Head to head with its named competitors (MGTX vs FDMT)
CompanyMarket cap6M returnRevenue growthOp. marginEV / SalesReq g
MeiraGTx MGTX$864M-8%+948%46%2.1×-9.9%
4D Molecular Therapeutics FDMT$677M+21%+278,712%-214%3.9×n/a

How MeiraGTx compares with its peers

Peer set: Industry: the same industry and sector in any market, nearest in size. This is the same default set the interactive Competitor Analysis opens with.

MeiraGTx against its 20 peers (data as of 6 Nov 2026)
MeasureMGTXPeer medianRank in peer set
1-month return-14.3%-5.6%7th lowest of 21
6-month return-8.3%-19.9%4th highest of 19
Distance from 52-week high-41.4%-43.9%9th highest of 21
Revenue growth (TTM)+948.4%-1.8%highest of 17
Operating margin45.9%-25.3%highest of 18
EV / Sales2.1×7.6×2nd cheapest of 18
Growth the price implies (Req g, 7 yrs)-9.9%11.1%2nd least demanding of 8
Growth delivered (Del g)+39.2%+4.4%highest of 8
Hurdle (Req g minus delivered)-49.1 pp+8.3 ppleast demanding of 8
ROIC minus cost of capital+68.2 pp-15.2 pphighest of 14
EV / EBITDA4.3×n/a—
Net debt / EBITDA-0.2×n/a—

Peer table

Peer set: Industry: the same industry and sector in any market, nearest in size
CompanyMarketMarket cap6M returnRevenue growthOp. marginEV / SalesReq gDelivered g
MeiraGTx MGTXUnited States$864M-8%+948%46%2.1×-9.9%+39.2%
GNI 2160.TJapan$866M-29%+10%-24%5.7×n/an/a
Syndax Pharmaceuticals SNDXUnited States$859M-56%+160%-62%3.5×n/an/a
Peptidream 4587.TJapan$856M-10%+1%-25%6.6×n/an/a
Prime Medicine PRMEUnited States$843M+45%-18%-4,825%211.3×n/an/a
Oxford BioMedica OXB.LUnited Kingdom$892M-14%+16%-18%4.3×n/an/a
Monte Rosa Therapeutics GLUEUnited States$902M-45%-84%-633%11.1×n/an/a
Inventiva IVA.PAFrance$912M-29%-100%-307,063%14,560.9×n/an/a
Wuhan Keqian Biology 688526.SSChina$814M-19%-22%20%4.7×8.8%+2.4%
Odyssey Therapeutics ODTXUnited States$924Mn/a-33%-5,415%208.9×n/an/a
Nanjing Leads Biolabs 9887.HKHong Kong$927M-54%n/a-108%26.5×n/an/a
R&G PharmaStudies 301333.SZChina$803M-12%+21%11%3.9×20.1%+11.8%
Anhui Wanbang Pharmaceutical Technology 301520.SZChina$803M+91%-15%-8%17.9×48.8%+14.7%
Beijing SL Pharmaceutical 002038.SZChina$793M-21%-4%-119%7.6×-12.3%-10.9%
Jade Biosciences JBIOUnited States$958M-42%n/an/an/an/an/a
China Animal Husbandry Industry 600195.SSChina$960M-17%+1%2%1.4×6.6%+4.4%
Alphamab Oncology 9966.HKHong Kong$777M-39%-32%-38%8.2×n/an/a
Shaanxi Micot Pharmaceutical Technology 2335.HKHong Kong$777Mn/an/an/an/an/an/a
Alto Neuroscience ANROUnited States$987M+4%n/an/an/an/an/a
Chengdu Kanghua Biological Products Co. Td Class 1 300841.SZChina$995M-11%0%22%4.7×11.1%+2.3%
Frontier Biotechnologies 688221.SSChina$746M-37%+153%-20%13.1×43.2%+21.5%

Questions

Who are MeiraGTx's main competitors?
Named competitors: Adverum Biotechnologies (private or unlisted), 4D Molecular Therapeutics (FDMT). The cockpit's measured peer set (industry) also includes GNI (2160.T), Syndax Pharmaceuticals (SNDX), Peptidream (4587.T), Prime Medicine (PRME), Oxford BioMedica (OXB.L), Monte Rosa Therapeutics (GLUE).
Is MeiraGTx expensive compared with its peers?
On ev / sales it trades at 2.1× against a peer median of 7.6×, 2nd cheapest of 18 in its peer set. For today's price to make sense, revenue must grow about -10% a year for seven years (Req g). Recent delivered growth is +39%, so the hurdle is -49 pp: the price already allows for a slowdown.
How has MeiraGTx stock performed?
Over six months to 6 Nov 2026 the shares returned -8.3% against -19.9% for the median peer; over one year +4.9%.

How these numbers are made. Returns are close-to-close in local currency. Revenue growth and margins are trailing twelve months. Req g is the revenue growth that today's enterprise value requires for seven years at the company's own cost of capital; Delivered g is what it actually grew; the gap is the hurdle (honest precision about ±8 points, so read the ranking more than the decimal). No fair values, price targets or analyst ratings are shown, by design. Method and validation.